Statistical manifolds and Fisher metric
A parametric family ${p(x;\theta) : \theta \in \Theta}$ forms a statistical manifold. The Fisher information matrix defines a Riemannian metric:
\[g_{ij}(\theta) = \mathbb{E}_\theta\!\left[\frac{\partial \ell}{\partial \theta^i}\frac{\partial \ell}{\partial \theta^j}\right] = -\mathbb{E}_\theta\!\left[\frac{\partial^2 \ell}{\partial \theta^i \partial \theta^j}\right]\]where $\ell = \log p(x;\theta)$ is the log-likelihood. The geodesic distance between distributions under this metric captures statistical distinguishability.
Cramér-Rao bound and $\alpha$-connections
The Cramér-Rao bound $\operatorname{Var}(\hat{\theta}) \geq g^{-1}(\theta)$ follows directly from the metric structure, bounding estimator variance from below. The $\alpha$-connections (due to Amari) define a one-parameter family of affine connections on the manifold; the $\pm 1$ connections correspond to exponential and mixture families respectively, which are dual under the Fisher metric.
Applications
Natural gradient descent replaces the ordinary gradient with $\tilde{\nabla} L = g^{-1}(\theta)\nabla L$, invariant to reparametrization and converging faster in practice. Applications include efficient training of neural networks, variational inference, expectation-maximization algorithms, and online learning in exponential families.