Life sciences
9 topics
Life sciences
Quant genetics
Quantitative genetics connects genotype to phenotype using linear models and variance decomposition. It underpins genome-wide association studies, heritability estimation, and animal breeding programmes.
Topics in this field
Epistasis
Gene-gene interactions and their contribution to phenotypic variance and GWAS inflation.
Genome-Wide Association Studies
Statistical methods for mapping SNP associations to complex traits across the genome.
Hardy-Weinberg Equilibrium
Allele and genotype frequency equilibrium under idealized random mating.
Heritability
Partitioning phenotypic variance into genetic and environmental components.
Linkage Disequilibrium
Non-random allelic associations between loci and their decay with recombination.
Polygenic Scores
Aggregating genome-wide SNP effects into individual-level genetic prediction scores.
Quantitative Trait Loci
Statistical mapping of genomic regions that contribute to variation in quantitative traits.
Response to Selection
The Breeder's equation and quantitative prediction of genetic gain per generation.
The Animal Model
BLUP breeding value estimation using pedigree relationships and mixed model equations.