math concept
28 topics use this
Math concept
Hypothesis Testing
Core equation
$$p = P(T \geq t_{\text{obs}} \mid H_0)$$
Hypothesis testing provides a formal framework for deciding whether data support a claim. It is the backbone of clinical trials, scientific experiments, and policy evaluation — and connects to information theory, decision theory, and Bayesian inference.
Framework
- State $H_0$ (null) and $H_1$ (alternative)
- Choose a test statistic $T$ whose distribution is known under $H_0$
- Compute $p = P(T \geq t_{\text{obs}} \mid H_0)$
- Reject $H_0$ if $p < \alpha$ (significance level, typically 0.05)
Type I and Type II errors
| $H_0$ true | $H_0$ false | |
|---|---|---|
| Reject $H_0$ | Type I error (rate $\alpha$) | Correct (power $1-\beta$) |
| Fail to reject | Correct | Type II error (rate $\beta$) |
Power $= 1 - \beta$ increases with sample size $n$, effect size, and $\alpha$.
The $p$-value misconception
A $p$-value is not the probability that $H_0$ is true given the data. It is $P(\text{data} \mid H_0)$, not $P(H_0 \mid \text{data})$. Confusing the two is a common error. Bayesian testing avoids it by computing the posterior directly.
Fields that use this concept
Finance & economics
Actuarial science
Life sciences
Bioinformatics
Comparative Genomics
Measuring evolutionary divergence between genomes through synteny, substitution rates, and neutrality tests.
Genome-Wide Association Studies
Statistical methods for linking genetic variants to traits or diseases across the entire genome.
RNA-Seq Differential Expression
Statistical modelling of read counts to identify genes that change expression between conditions.
Life sciences
Biostatistics
Clinical Trial Design
Principled design of randomized controlled trials, covering sample size, error control, adaptive methods, and regulatory frameworks.
Generalized Linear Models
A unified regression framework extending linear models to non-normal outcomes via exponential family distributions and link functions.
Kaplan-Meier Estimator
The product-limit non-parametric estimator of the survival function, the universal starting point for time-to-event analysis.
Logistic Regression
Regression model for binary and polytomous outcomes using the logit link, yielding odds ratio estimates directly interpretable in clinical and epidemiological research.
Meta-Analysis
Quantitative synthesis of results across multiple studies, combining effect estimates to increase precision and assess heterogeneity.
Multiple Testing Corrections
Methods for controlling error rates when simultaneously testing many hypotheses, from conservative Bonferroni corrections to FDR control in genomics.
Finance & economics
Econometrics
ARIMA & Time Series
Modelling autocorrelated sequences. Connects deeply to signal processing and Fourier analysis.
Cointegration
Long-run equilibrium between non-stationary time series. Bridges econometrics and finance.
Difference-in-Differences
Estimating treatment effects using panel data. The go-to design for policy evaluation.
Generalized Method of Moments
A general estimation framework that exploits population moment conditions to identify and estimate model parameters with minimal distributional assumptions.
Instrumental Variables
Causal inference when OLS is biased by endogeneity. Uses a third variable to isolate exogenous variation.
Maximum Likelihood Estimation
Estimating parameters by maximising the probability of observed data. Foundation of modern statistical inference.
Panel Data and Fixed Effects
Methods for estimating causal effects from panel data by exploiting within-unit variation to control for time-invariant unobserved heterogeneity.
Regression Discontinuity Design
A quasi-experimental method that identifies causal effects by exploiting sharp discontinuities in treatment assignment driven by a continuous running variable crossing a known cutoff.
Engineering & CS
Machine learning
Classical Test Theory
The foundational framework decomposing an observed score into a true score and random measurement error.
Differential Item Functioning
Detection of items that favor one group over another after matching on the latent trait being measured.
Reliability and Validity
Core psychometric properties evaluating the consistency and accuracy of a measurement instrument.
Life sciences
Quant genetics
Epistasis
Gene-gene interactions and their contribution to phenotypic variance and GWAS inflation.
Genome-Wide Association Studies
Statistical methods for mapping SNP associations to complex traits across the genome.
Hardy-Weinberg Equilibrium
Allele and genotype frequency equilibrium under idealized random mating.
Linkage Disequilibrium
Non-random allelic associations between loci and their decay with recombination.
Quantitative Trait Loci
Statistical mapping of genomic regions that contribute to variation in quantitative traits.
Engineering & CS
Signal processing